Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 70, Issue 19, Pages 3513-3524Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1256-2
Keywords
NuRD complex; Chromatin
Categories
Funding
- NIH [GM096863]
- Intramural Research Program of the US National Institute of Environmental Health Sciences, NIH [Z01ES101965]
- Neuroscience Graduate training grant [T32HD041697]
Ask authors/readers for more resources
The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin organization, gene transcription, genomic stability and developmental signaling. NuRD has a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among its six core subunits. Recent studies indicate that NuRD composition and the interplay between subunits may dictate the diverse functions of the complex. In this review, we examine the structures and biological roles of the NuRD subunits and discuss new avenues of research to advance our understanding of the NuRD-mediated signaling network.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available