4.7 Review

The role of inflammation in sporadic and familial Parkinson's disease

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinsons disease

Peter Holmans et al.

HUMAN MOLECULAR GENETICS (2013)

Article Neurosciences

Interplay of LRRK2 with chaperone-mediated autophagy

Samantha J. Orenstein et al.

NATURE NEUROSCIENCE (2013)

Article Neurosciences

Colonic inflammation in Parkinson's disease

David Devos et al.

NEUROBIOLOGY OF DISEASE (2013)

Article Clinical Neurology

Infectious burden and cognitive function The Northern Manhattan Study

Mira Katan et al.

NEUROLOGY (2013)

Article Medicine, General & Internal

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Thorlakur Jonsson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

TREM2 Variants in Alzheimer's Disease

Rita Guerreiro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

Carmen Noelker et al.

SCIENTIFIC REPORTS (2013)

Review Medicine, Research & Experimental

The immunology of neurodegeneration

Eva Czirr et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Medicine, Research & Experimental

Innate immunity in the central nervous system

Richard M. Ransohoff et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Neurosciences

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

Mark S. Moehle et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Neurosciences

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

Penelope J. Hallett et al.

NEUROBIOLOGY OF DISEASE (2012)

Article Clinical Neurology

Large-scale replication and heterogeneity in Parkinson disease genetic loci

Manu Sharma et al.

NEUROLOGY (2012)

Article Multidisciplinary Sciences

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

Beomsue Kim et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Gaucher disease gene GBA functions in immune regulation

Jun Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Pharmacology & Pharmacy

Inflammation and neurodegeneration: the story 'retolled'

Janelle Drouin-Ouellet et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2012)

Article Medicine, Research & Experimental

Inflammation and Adaptive Immunity in Parkinson's Disease

R. Lee Mosley et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Pharmacology & Pharmacy

Imaging of microglia in patients with neurodegenerative disorders

Marios Politis et al.

FRONTIERS IN PHARMACOLOGY (2012)

Article Pathology

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

Nadia Stefanova et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Biochemistry & Molecular Biology

Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions

Micha M. M. Wilhelmus et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Biochemistry & Molecular Biology

Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease

Tamar Farfel-Becker et al.

HUMAN MOLECULAR GENETICS (2011)

Article Clinical Neurology

Possible Involvement of Complement Factor C1q in the Clearance of Extracellular Neuromelanin From the Substantia Nigra in Parkinson Disease

Candan Depboylu et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)

Review Clinical Neurology

Milestones in PD Genetics

Thomas Gasser et al.

MOVEMENT DISORDERS (2011)

Review Clinical Neurology

Glia: Initiators and Progressors of Pathology in Parkinson's Disease

Glenda M. Halliday et al.

MOVEMENT DISORDERS (2011)

Article Clinical Neurology

GBA-associated PD presents with nonmotor characteristics

K. Brockmann et al.

NEUROLOGY (2011)

Article Clinical Neurology

Use of ibuprofen and risk of Parkinson disease

Xiang Gao et al.

NEUROLOGY (2011)

Article Clinical Neurology

Human leukocyte antigen variation and Parkinson's disease

Andreas Puschmann et al.

PARKINSONISM & RELATED DISORDERS (2011)

Article Multidisciplinary Sciences

Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke

Connie H. Y. Wong et al.

SCIENCE (2011)

Article Multidisciplinary Sciences

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

Mauricio Rosas-Ballina et al.

SCIENCE (2011)

Review Neurosciences

Toll-like receptor signaling in neural plasticity and disease

Eitan Okun et al.

TRENDS IN NEUROSCIENCES (2011)

Article Neurosciences

alpha-Synuclein alters toll-like receptor expression

Dawn Beraud et al.

FRONTIERS IN NEUROSCIENCE (2011)

Review Clinical Neurology

Prospects for Minocycline Neuroprotection

Jennifer M. Plane et al.

ARCHIVES OF NEUROLOGY (2010)

Article Biochemistry & Molecular Biology

Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions

Jack van Horssen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Biochemistry & Molecular Biology

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

He-Jin Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Immunology

LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens

Agnes Gardet et al.

JOURNAL OF IMMUNOLOGY (2010)

Article Clinical Neurology

Association of the human leucocyte antigen region with susceptibility to Parkinson's disease

Misuzu Saiki et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2010)

Article Neurosciences

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Kiran Bhaskar et al.

NEURON (2010)

Article Multidisciplinary Sciences

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

Youren Tong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage

Pramod K. Mistry et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1

Jens Waak et al.

FASEB JOURNAL (2009)

Article Genetics & Heredity

Whole Genome Survey of Coding SNPs Reveals a Reproducible Pathway Determinant of Parkinson Disease

Balaji S. Srinivasan et al.

HUMAN MUTATION (2009)

Review Cell Biology

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

Hristelina Ilieva et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Clinical Neurology

Systemic inflammation and disease progression in Alzheimer disease

C. Holmes et al.

NEUROLOGY (2009)

Review Neurosciences

Immune Proteins in Brain Development and Synaptic Plasticity

Lisa M. Boulanger

NEURON (2009)

Article Neurosciences

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

Xiaomin Su et al.

NEUROTOXICITY RESEARCH (2009)

Article Medicine, General & Internal

Genomewide Association Study of Leprosy

Fu-Ren Zhang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Medicine, General & Internal

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

E. Sidransky et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Multidisciplinary Sciences

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

Chee Yeun Chung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Neurosciences

Nitrated alpha-synuclein and microglial neuroregulatory activities

Ashley D. Reynolds et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2008)

Article Clinical Neurology

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

Shaji Theodore et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)

Article Neurosciences

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

Tamy C. Frank-Cannon et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Genetics & Heredity

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Jeffrey C. Barrett et al.

NATURE GENETICS (2008)

Article Geriatrics & Gerontology

Synuclein activates microglia in a model of Parkinson's disease

Xiaomin Su et al.

NEUROBIOLOGY OF AGING (2008)

Article Geriatrics & Gerontology

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

Andis Klegeris et al.

NEUROBIOLOGY OF AGING (2008)

Article Clinical Neurology

Interleukin-10 (IL10) and tumor necrosis factor α (TNF) gene polymorphisms in Parkinson's disease patients

M. Bialecka et al.

PARKINSONISM & RELATED DISORDERS (2008)

Article Biochemistry & Molecular Biology

Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease

Ashley D. Reynolds et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

The classical complement cascade mediates CNS synapse elimination

Beth Stevens et al.

Article Clinical Neurology

Circulating interleukin-15 and RANTES chemokine in Parkinson's disease

M. Rentzos et al.

ACTA NEUROLOGICA SCANDINAVICA (2007)

Article Clinical Neurology

Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease

Angelika D. Wahner et al.

NEUROLOGY (2007)

Review Neurosciences

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

Uwe-Karsten Hanisch et al.

NATURE NEUROSCIENCE (2007)

Article Clinical Neurology

Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan

Y. R. Wu et al.

JOURNAL OF NEURAL TRANSMISSION (2007)

Article Biochemistry & Molecular Biology

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

Julia W. Pridgeon et al.

PLOS BIOLOGY (2007)

Review Neurosciences

Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

David Sulzer

TRENDS IN NEUROSCIENCES (2007)

Article Biochemistry & Molecular Biology

Autoantibodies to alpha-synuclein in inherited Parkinson's disease

Katerina K. Papachroni et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Article Genetics & Heredity

Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease

Yih-Ru Wu et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2007)

Article Neurosciences

P53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain

Makio Mogi et al.

NEUROSCIENCE LETTERS (2007)

Article Neurosciences

VIP is a transcriptional target of Nurr1 in dopaminergic cells

Yu Luo et al.

EXPERIMENTAL NEUROLOGY (2007)

Article Clinical Neurology

Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease

Angelika D. Wahner et al.

ARCHIVES OF NEUROLOGY (2007)

Article Neurosciences

CARD15 variants in patients with sporadic Parkinson's disease

Monika Bialecka et al.

NEUROSCIENCE RESEARCH (2007)

Review Immunology

What is immune privilege (not)?

Ian Galea et al.

TRENDS IN IMMUNOLOGY (2007)

Article Neurosciences

α-synuclein expression modulates microglial activation phenotype

Susan A. Austin et al.

JOURNAL OF NEUROSCIENCE (2006)

Article Multidisciplinary Sciences

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Casey M. Clements et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Clinical Neurology

LRRK2 expression in normal and pathologic human brain and in human cell lines

Judith Miklossy et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)

Article Clinical Neurology

Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease

Thanh G. Ton et al.

MOVEMENT DISORDERS (2006)

Article Clinical Neurology

Trial of celecoxib in amyotrophic lateral sclerosis

Merit E. Cudkowicz et al.

ANNALS OF NEUROLOGY (2006)

Article Neurosciences

Control of microglial neurotoxicity by the fractalkine receptor

Astrid E. Cardona et al.

NATURE NEUROSCIENCE (2006)

Review Multidisciplinary Sciences

Lewy bodies

CW Shults

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Neurosciences

Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys

J Miklossy et al.

EXPERIMENTAL NEUROLOGY (2006)

Article Clinical Neurology

A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females

JJ Lin et al.

PARKINSONISM & RELATED DISORDERS (2006)

Review Clinical Neurology

The diagnosis of Parkinson's disease

E Tolosa et al.

LANCET NEUROLOGY (2006)

Article Biochemistry & Molecular Biology

Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli

LM Pei et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Clinical Neurology

Investigation of genes coding for inflammatory components in Parkinson's disease

A Håkansson et al.

MOVEMENT DISORDERS (2005)

Article Genetics & Heredity

Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease

A Håkansson et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2005)

Article Clinical Neurology

Microglial activation and dopamine terminal loss in early Parkinson's disease

Y Ouchi et al.

ANNALS OF NEUROLOGY (2005)

Article Clinical Neurology

Blood-brain barrier dysfunction in Parkinsonian midbrain in vivo

R Kortekaas et al.

ANNALS OF NEUROLOGY (2005)

Article Clinical Neurology

Alterations of T-lymphocyte populations in Parkinson disease

Y Baba et al.

PARKINSONISM & RELATED DISORDERS (2005)

Article Multidisciplinary Sciences

Susceptibility to leprosy is associated with PARK2 and PACRG

MT Mira et al.

NATURE (2004)

Article Neurosciences

Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease

E Diguet et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2004)

Article Biochemistry & Molecular Biology

APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response

JR Lynch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Clinical Neurology

Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease

HL Chen et al.

ARCHIVES OF NEUROLOGY (2003)

Article Medicine, General & Internal

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - A randomized controlled trial

PS Aisen et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

Article Multidisciplinary Sciences

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

P Teismann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein:: A new primate model of Parkinson's disease

D Kirik et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Clinical Neurology

HLA typing and Parkinson's disease

JB Lampe et al.

EUROPEAN NEUROLOGY (2003)

Review Multidisciplinary Sciences

The inflammatory reflex

KJ Tracey

NATURE (2002)

Article Biochemistry & Molecular Biology

Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress

MD Ledesma et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Article Clinical Neurology

Broad expression of Toll-like receptors in the human central nervous system

M Bsibsi et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)

Article Neurosciences

Association of interieukin-1β polymorphisms with idiopathic Parkinson's disease

PL McGeer et al.

NEUROSCIENCE LETTERS (2002)

Article Genetics & Heredity

Association of an interleukin 1B gene polymorphism (-511) with Parkinson's disease in Finnish patients

KM Mattila et al.

JOURNAL OF MEDICAL GENETICS (2002)

Review Neurosciences

Innate immunity: The missing link in neuroprotection and neurodegeneration?

MD Nguyen et al.

NATURE REVIEWS NEUROSCIENCE (2002)

Article Neurosciences

Tumor necrosis factor gene polymorphisms in patients with sporadic Parkinson's disease

M Nishimura et al.

NEUROSCIENCE LETTERS (2001)

Article Neurosciences

Integrity of the blood-cerebrospinal fluid barrier in early Parkinson's disease

P Haussermann et al.

NEUROSCIENCE LETTERS (2001)

Article Immunology

Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism

J Bas et al.

JOURNAL OF NEUROIMMUNOLOGY (2001)

Review Neurosciences

Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and-2

C Knott et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2000)

Article Multidisciplinary Sciences

Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

RM Hoek et al.

SCIENCE (2000)

Article Clinical Neurology

Genetic analysis of immunomodulating factors in sporadic Parkinson's disease

R Kruger et al.

JOURNAL OF NEURAL TRANSMISSION (2000)