Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 70, Issue 22, Pages 4229-4241Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1348-7
Keywords
Heat shock; Heat shock proteins; DNA replication; DNA damage; Transcription
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Funding
- Ministry of Science and Education of the Russian Federation [8126, 8052]
- Russian Foundation for Basic Research [12-04-33040, 13-04-00604]
- Presidium of the Russian Academy of Sciences
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Heat shock (HS) is one of the best-studied exogenous cellular stresses. The cellular response to HS utilizes ancient molecular networks that are based primarily on the action of stress-induced heat shock proteins and HS factors. However, in one way or another, all cellular compartments and metabolic processes are involved in such a response. In this review, we aimed to summarize the experimental data concerning all aspects of the HS response in mammalian cells, such as HS-induced structural and functional alterations of cell membranes, the cytoskeleton and cellular organelles; the associated pathways that result in different modes of cell death and cell cycle arrest; and the effects of HS on transcription, splicing, translation, DNA repair, and replication.
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