Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 70, Issue 10, Pages 1705-1725Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1279-3
Keywords
VEGF receptors; Neurogenesis; Neural stem cells; Brain development; Brain repair; Migration
Categories
Funding
- Deutsche Forschungsgemeinschaft [SPP1109, PL 158/5-1, PL 158/5-2, PL 158/5-3]
- German Israeli Foundation [I-740-102.1]
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Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood. Therefore, the VEGF system serves as a promising therapeutic target for brain pathologies, but its simultaneous action on vascular cells paves the way for harmful side effects. To circumvent these deleterious effects, many studies have aimed to clarify whether VEGFs directly affect neural cells or if the effects are mediated secondarily via other cell types, like vascular cells. A great number of reports have shown the expression and function of VEGF receptors (VEGFRs), mainly VEGFR-1 and -2, in neural cells, where VEGFR-2 has been described as the major mediator of VEGF-A signals. This review aims to summarize and compare the divergent roles of VEGFR-1 and -2 during CNS development and homeostasis.
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