Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 69, Issue 13, Pages 2135-2146Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-0917-5
Keywords
Sphingolipid; Obesity; Inflammation; TLR4
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Following the initial discovery that adipose tissue actively synthesizes and secretes cytokines, obesity-induced inflammation has been implicated in the etiology of a host of disease states related to obesity, including cardiovascular disease and type II diabetes. Interestingly, a growing body of evidence similarly implicates sphingolipids as prime instigators in these same diseases. From the recent discovery that obesity-related inflammatory pathways modulate sphingolipid metabolism comes a novel perspective-sphingolipids may act as the dominant mediators of deleterious events stemming from obesity-induced inflammation. This paradigm may identify sphingolipids as an effective target for future therapeutics aimed at ameliorating diseases associated with chronic inflammation.
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