Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 69, Issue 15, Pages 2485-2499Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-0926-4
Keywords
GABA(A) receptor; Gephyrin; Neuroligin, collybistin, dystrophin-glycoprotein complex; Synaptic plasticity
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Funding
- Swiss National Science Foundation [31003A_130495]
- San Paolo Foundation [2008-2254]
- University of Turin
- Forschungskredit of the University of Zurich
- Swiss National Science Foundation (SNF) [31003A_130495] Funding Source: Swiss National Science Foundation (SNF)
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Knowledge of the functional organization of the GABAergic system, the main inhibitory neurotransmitter system, in the CNS has increased remarkably in recent years. In particular, substantial progress has been made in elucidating the molecular mechanisms underlying the formation and plasticity of GABAergic synapses. Evidence available ascribes a key role to the cytoplasmic protein gephyrin to form a postsynaptic scaffold anchoring GABA(A) receptors along with other transmembrane proteins and signaling molecules in the postsynaptic density. However, the mechanisms of gephyrin scaffolding remain elusive, notably because gephyrin can auto-aggregate spontaneously and lacks PDZ protein interaction domains found in a majority of scaffolding proteins. In addition, the structural diversity of GABA(A) receptors, which are pentameric channels encoded by a large family of subunits, has been largely overlooked in these studies. Finally, the role of the dystrophin-glycoprotein complex, present in a subset of GABAergic synapses in cortical structures, remains ill-defined. In this review, we discuss recent results derived mainly from the analysis of mutant mice lacking a specific GABA(A) receptor subtype or a core protein of the GABAergic postsynaptic density (neuroligin-2, collybistin), highlighting the molecular diversity of GABAergic synapses and its relevance for brain plasticity and function. In addition, we discuss the contribution of the dystrophin-glycoprotein complex to the molecular and functional heterogeneity of GABAergic synapses.
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