Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 69, Issue 17, Pages 2863-2878Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-0957-x
Keywords
Cerebrospinal fluid; Choroid plexus; Neurogenesis; Traumatic brain injury
Categories
Funding
- Eleanor and Miles Shore Fellowship Program for Scholars in Medicine/Children's Hospital Boston Career Development Award
- NIH [R00 NS072192]
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The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu that regulates brain development, homeostasis, and disease. Advances in proteomics research have enabled an improved characterization of the CSF from development through adulthood, and key neurogenic signaling pathways that are transmitted via the CSF are now being elucidated. Due to its immediate contact with neural stem cells in the developing and adult brain, the CSF's ability to swiftly distribute signals across vast distances in the central nervous system is opening avenues to novel and exciting therapeutic approaches. In this review, we will discuss the development of the choroid plexus-CSF system, and review the current literature on how the CSF actively regulates mammalian brain development, behavior, and responses to traumatic brain injury.
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