Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 70, Issue 12, Pages 2059-2081Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1152-9
Keywords
Wound healing; Regeneration; Skin; Wnt; beta-Catenin; Transforming growth factor beta (TGF-beta); Notch; Hedgehog
Categories
Funding
- Canadian Institutes of Health Research [FRN 15136]
- Ontario Institute for Cancer Research
- Canada Research Chairs Programme
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Following a skin injury, the damaged tissue is repaired through the coordinated biological actions that constitute the cutaneous healing response. In mammals, repaired skin is not identical to intact uninjured skin, however, and this disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryonic skin development. Improving our understanding of the molecular pathways that are involved in these processes is essential to generate new therapies for wound healing complications. Here we focus on the roles of several key developmental signaling pathways (Wnt/beta-catenin, TGF-beta, Hedgehog, Notch) in mammalian cutaneous wound repair, and compare this to their function in skin development. We discuss the varying responses to cutaneous injury across the taxa, ranging from complete regeneration to scar tissue formation. Finally, we outline how research into the role of developmental pathways during skin repair has contributed to current wound therapies, and holds potential for the development of more effective treatments.
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