Journal
ARTHRITIS RESEARCH & THERAPY
Volume 4, Issue -, Pages S169-S176Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar558
Keywords
cytokines; inflammation; monocytes; rheumatoid arthritis; T lymphocytes
Categories
Funding
- Swiss National Science Foundation [31-50930-97]
- Swiss Society for Multiple Sclerosis
- Hans Wilsdorf Foundation
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Contact-mediated signaling of monocytes by human stimulated T lymphocytes (T-L) is a potent proinflammatory mechanism that triggers massive upregulation of the proinflammatory cytokines IL-1 and tumor necrosis factor-alpha. These two cytokines play an important part in chronic destructive diseases, including rheumatoid arthritis. To date this cell-cell contact appears to be a major endogenous mechanism to display such an activity in monocyte-macrophages. Since T-L and monocyte-macrophages play a pivotal part in the pathogenesis of chronic inflammatory diseases, we investigated the possible ligands and counter-ligands involved in this cell-cell interaction. We also characterized an inhibitory molecule interfering in this process, apolipoprotein A-I. This review aims to summarize the state of the art and importance of contact-mediated monocyte activation by stimulated T-L in cytokine production in rheumatoid arthritis and mechanisms that might control it.
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