Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 70, Issue 15, Pages 2677-2696Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1187-y
Keywords
Cancer; Sox4; Oncogene; Tumor suppressor
Categories
Funding
- Canadian Institutes of Health Research [MOP-84559, MOP-93810, MOP-110974]
- Canadian Cancer Society Research Institute [2011-700714]
- Canadian Dermatology Foundation
- Canadian Institute of Health Research Skin Research Training Centre
- Roman M. Babicki Fellowship
- University of British Columbia Graduate Fellowship
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In addition to their critical roles in embryonic development, cell fate decision, and differentiation, members of Sox (Sry-related high-mobility group box) family of transcription factors including Sox4 have been implicated in various cancers. Multiple studies have revealed an increased expression along with specific oncogenic function of Sox4 in tumors, while others observed a reduced expression of Sox4 in different types of malignancies and suppression of tumor initiation or progression by this protein. More interestingly, the prognostic value of Sox4 is debated due to obvious differences between various reports as well as inconsistencies within specific studies. This review summarizes our current understanding of Sox4 expression pattern and its transcription-dependent, as well as transcription-independent, functions in tumor initiation or progression and its correlation with patient survival. We also discuss the existing discrepancies between different reports and their possible explanations.
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