Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 19, Pages 3175-3199Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0783-6
Keywords
Tenascin-C; Cardiac injury; Vascular imaging; Stem cells; Tumor metastasis
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Funding
- Arthritis Research UK
- Institut National du Cancer
- Institut National de la Sante et de la Recherche Medicale
- Universite de Strasbourg
- Association pour la Recherche contre le Cancer
- Agence National de la recherche
- Hospital Hautepierre
- Medical Research Council [G0700108] Funding Source: researchfish
- MRC [G0700108] Funding Source: UKRI
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Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.
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