Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 9, Pages 1481-1489Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0656-z
Keywords
Antigen processing; MHC class I; Proteasome; Translation; Virus
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Funding
- Division of Intramural Research, NIAID, Bethesda, MD
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It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells. Here, we review the evidence for the contribution of DRiPs to antigen processing, pointing to the uncertainties regarding the physical nature of DRiPs, and emphasizing recent findings suggesting that peptide generation is a specialized process involving compartmentalized translation.
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