Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 12, Pages 2067-2079Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0682-x
Keywords
Ferrous iron (Fe(II)); Fenton reaction; Hydroxyl radical; Microdialysis; Radical traps; Singlet oxygen
Categories
Funding
- Fonds zur Forderung der Wissenschaftlichen Forschung in Osterreich [19335-N17]
- Ente Cassa di Risparmio di Firenze (Firenze, Italy)
- Universita degli Studi di Firenze, Science Foundation Ireland
- ERAB: The European Foundation for Alcohol Research (Brussels, Belgium)
- EU COST action
Ask authors/readers for more resources
The so-called reactive oxygen species (ROS) are defined as oxygen-containing species that are more reactive than O-2 itself, which include hydrogen peroxide and superoxide. Although these are quite stable, they may be converted in the presence of transition metal ions, such as Fe(II), to the highly reactive oxygen species (hROS). hROS may exist as free hydroxyl radicals (HO center dot), as bound (crypto) radicals or as Fe(IV)-oxo (ferryl) species and the somewhat less reactive, non-radical species, singlet oxygen. This review outlines the processes by which hROS may be formed, their damaging potential, and the evidence that they might have signaling functions. Since our understanding of the formation and actions of hROS depends on reliable procedures for their detection, particular attention is given to procedures for hROS detection and quantitation and their applicability to in vivo studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available