Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 21, Pages 3495-3503Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0800-9
Keywords
Transcription factor; NK cell differentiation; Migration; Effector function
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Funding
- Swiss National Science Foundation [31-109832]
- Medical Research Council-UK [G0802068, G0901737]
- Department of Health via the National Institute for Health research (NIHR) comprehensive Biomedical Research Centre
- MRC [G0901737, G0802068] Funding Source: UKRI
- Medical Research Council [G1000758B, G0802068, G1000758, G0600698B, G0901737] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10212] Funding Source: researchfish
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Gene expression can be modulated depending on physiological and developmental requirements. A multitude of regulatory genes, which are organized in interdependent networks, guide development and eventually generate specific phenotypes. Transcription factors (TF) are a key element in the regulatory cascade controlling cell fate and effector functions. In this review, we discuss recent data on the diversity of TF that determine natural killer (NK) cell fate and NK cell function.
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