Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 13, Pages 2189-2199Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0712-8
Keywords
Antimicrobial peptides; Defensin; Cathelicidin; Innate immunity; Skin diseases; Keratinocytes
Categories
Funding
- NIAID NIH HHS [R01 AI052453-10, R01 AI052453, R01 AI083358, R37 AI052453, R56 AI083358] Funding Source: Medline
- NIAMS NIH HHS [R01 AR052728] Funding Source: Medline
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The skin is our primary shield against microbial pathogens and has evolved innate and adaptive strategies to enhance immunity in response to injury or microbial insult. The study of antimicrobial peptide (AMP) production in mammalian skin has revealed several of the elegant strategies that AMPs use to prevent infection. AMPs are inducible by both infection and injury and protect the host by directly killing pathogens and/or acting as multifunctional effector molecules that trigger cellular responses to aid in the anti-infective and repair response. Depending on the specific AMP, these molecules can influence cytokine production, cell migration, cell proliferation, differentiation, angiogenesis and wound healing. Abnormal production of AMPs has been associated with the pathogenesis of several cutaneous diseases and plays a role in determining a patient's susceptibility to pathogens. This review will discuss current research on the regulation and function of AMPs in the skin and in skin disorders.
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