Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 22, Pages 3635-3641Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0822-3
Keywords
Mucus; Mucin; MUC2; Colon; Commensal bacteria; Small intestine
Categories
Funding
- Swedish Research Council [7461, 21027, 342-2004-4434]
- Swedish Cancer Foundation
- Knut and Alice Wallenberg Foundation [KAW2007.0118]
- IngaBritt and Arne Lundberg Foundation, Sahlgren's University Hospital (LUA-ALF)
- EU [200931]
- Wilhelm and Martina Lundgren's Foundation
- Torsten och Ragnar Soderbergs Stiftelser
- Sahlgrenska Academy Foundations
- Swedish Foundation for Strategic Research-The Mucosal Immunobiology and Vaccine Center (MIVAC)
- Mucus-Bacteria-Colitis Center (MBC)
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In discussions on intestinal protection, the protective capacity of mucus has not been very much considered. The progress in the last years in understanding the molecular nature of mucins, the main building blocks of mucus, has, however, changed this. The intestinal enterocytes have their apical surfaces covered by transmembrane mucins and the whole intestinal surface is further covered by mucus, built around the gel-forming mucin MUC2. The mucus of the small intestine has only one layer, whereas the large intestine has a two-layered mucus where the inner, attached layer has a protective function for the intestine, as it is impermeable to the luminal bacteria.
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