Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 19, Pages 3201-3207Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0784-5
Keywords
Periostin; Fibrillogenesis; Bone; Type I collagen; Tooth; Heart; Matricellular protein; ECM
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Funding
- Ministry of Education, Science, Culture, and Sports of Japan
- Japan Space Forum
- Grants-in-Aid for Scientific Research [23370090] Funding Source: KAKEN
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More than 10 years have passed since the naming of periostin derived from its expression sites in the periosteum and periodontal ligament. Following this finding, we have accumulated more data on the expression patterns of periostin, and, finally, with the generation of periostin-deficient mice, have revealed functions of periostin in the regeneration of tissues in bone, tooth, heart, and skin, and its action in cancer invasion. Since periostin is a matricellular protein, the first investigation of periostin function showed its enhancement of cell migration by acting outside the cell. On the other hand, recent observations have demonstrated that periostin functions in fibrillogenesis in association with extracellular matrix molecules inside the cell.
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