Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 23, Pages 3797-3814Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0753-z
Keywords
Isoprenoid biosynthesis; Terpenes; Isp proteins; Isopentenyl diphosphate; Dimethylallyl diphosphate; Mevalonate; Deoxyxylulose; Methyerythritol
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Funding
- Deutsche Forschungsgemeinschaft
- Hans-Fischer-Gesellschaft
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The non-mevalonate pathway of isoprenoid (terpenoid) biosynthesis is essential in many eubacteria including the major human pathogen, Mycobacterium tuberculosis, in apicomplexan protozoa including the Plasmodium spp. causing malaria, and in the plastids of plants. The metabolic route is absent in humans and is therefore qualified as a promising target for new anti-infective drugs and herbicides. Biochemical and structural knowledge about all enzymes involved in the pathway established the basis for discovery and development of inhibitors by high-throughput screening of compound libraries and/or structure-based rational design.
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