Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 12, Pages 2003-2012Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0616-z
Keywords
Axon-glia interaction; Src family kinase; Myelin; L1-CAM; Translational control; hnRNP-A2; Integrin; Contactin
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Funding
- European Leukodystrophy Association
- University of Mainz
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Central nervous system myelination requires recognition and signalling processes between neuronal axons and oligodendrocytes. Complex cellular rearrangements occur in myelination-competent oligodendrocytes requiring spatio-temporal control mechanisms. Although the molecular repertoire is becoming increasingly transparent, the signalling mechanisms governing myelination initiation are only poorly understood. The non-receptor tyrosine kinase Fyn has been implicated in axon-glial signal transduction and in several cellular processes required for oligodendrocyte maturation and myelination. Here, we review oligodendroglial Fyn signalling and discuss the role of Fyn in axon-glia interaction mediating myelination.
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