Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 69, Issue 7, Pages 1077-1104Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0845-9
Keywords
Ca2+ stores; Mitochondria; Ca2+ releasing channels; Ca2+ pumps; Sub-cellular signaling; Ca2+ microdomains
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Funding
- Italian Ministry of University and Research (MIUR)
- University of Padua
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An increase in the concentration of cytosolic free Ca2+ is a key component regulating different cellular processes ranging from egg fertilization, active secretion and movement, to cell differentiation and death. The multitude of phenomena modulated by Ca2+, however, do not simply rely on increases/decreases in its concentration, but also on specific timing, shape and sub-cellular localization of its signals that, combined together, provide a huge versatility in Ca2+ signaling. Intracellular organelles and their Ca2+ handling machineries exert key roles in this complex and precise mechanism, and this review will try to depict a map of Ca2+ routes inside cells, highlighting the uniqueness of the different Ca2+ toolkit components and the complexity of the interactions between them.
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