Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 67, Issue 16, Pages 2685-2693Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0375-x
Keywords
Monocyte subsets; Inflammation; Hematopoietic system; Macrophage; Dendritic cell
Categories
Funding
- NIH [1R01HL095612]
- AHA
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Monocytes participate importantly in immunity. Produced in the bone marrow and released into the blood, they circulate in blood or reside in a spleen reservoir before entering tissue and giving rise to macrophages or dendritic cells. Monocytes are more than transitional cells that adapt to a particular tissue environment indiscriminately. Accumulating evidence now indicates that monocytes are heterogeneous in several species and are themselves predetermined for particular function in the steady state and inflammation. Future therapeutics may harness this heterogeneity to target harmful functions while sparing those that are beneficial. Here, we review recent advances on the ontogeny and function of monocytes and their subsets in humans and mice.
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