Organic synthesis in solid media. Solvent-free Horner-Wadsworth-Emmons reaction in silica gel

Silica gel was found to be an excellent medium for the aldehyde-selective Horner-Wadsworth-Emmons reaction, which proceeds at room temperature in a short period of time under solvent-free conditions. The silica gel used for the reaction can be recovered and reused many times without losing its activity.