Related references
Note: Only part of the references are listed.Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
Sonja J. Heidorn et al.
CELL (2010)
Drosophila Raf's N Terminus Contains a Novel Conserved Region and Can Contribute to Torso RTK Signaling
Jian Ding et al.
GENETICS (2010)
Molecular and Clinical Analysis of RAF1 in Noonan Syndrome and Related Disorders: Dephosphorylation of Serine 259 as the Essential Mechanism for Mutant Activation
Tomoko Kobayashi et al.
HUMAN MUTATION (2010)
The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf
Rie Matsunaga-Udagawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels and Consequent Suppression of Inhibitory Raf-1 Phosphorylation
Geoffrey K. Kilili et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling
Daniel A. Ritt et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein
Sayaka Yoshiki et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos et al.
NATURE (2010)
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou et al.
NATURE (2010)
Molecular mechanisms in signal transduction at the membrane
Jay T. Groves et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
A RasGTP-Induced Conformational Change in C-RAF Is Essential for Accurate Molecular Recognition
Kayo Hibino et al.
BIOPHYSICAL JOURNAL (2009)
Raf-1 Addiction in Ras-Induced Skin Carcinogenesis
Karin Ehrenreiter et al.
CANCER CELL (2009)
Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells
Jayajit Das et al.
CELL (2009)
KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity
Diane L. Costanzo-Garvey et al.
CELL METABOLISM (2009)
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch
Amardeep S. Dhillon et al.
CELLULAR SIGNALLING (2009)
Diacylglycerol Kinase η Augments C-Raf Activity and B-Raf/C-Raf Heterodimerization
Satoshi Yasuda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-α kinase activity
Theodora Niault et al.
JOURNAL OF CELL BIOLOGY (2009)
Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway
Sung-Young Shin et al.
JOURNAL OF CELL SCIENCE (2009)
Ras Subcellular Localization Defines Extracellular Signal-Regulated Kinase 1 and 2 Substrate Specificity through Distinct Utilization of Scaffold Proteins
Berta Casar et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
C-Raf Inhibits MAPK Activation and Transformation by B-RafV600E
Florian A. Karreth et al.
MOLECULAR CELL (2009)
KSR2 Is a Calcineurin Substrate that Promotes ERK Cascade Activation in Response to Calcium Signals
Michele K. Dougherty et al.
MOLECULAR CELL (2009)
A dimerization-dependent mechanism drives RAF catalytic activation
Thanashan Rajakulendran et al.
NATURE (2009)
Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair
Viviana Cordeddu et al.
NATURE GENETICS (2009)
Signaling dynamics of the KSR1 scaffold complex
Melissa M. McKay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
K-Ras nanoclustering is subverted by overexpression of the scaffold protein Galectin-3
Ruby Shalom-Feuerstein et al.
CANCER RESEARCH (2008)
The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK
Oliver Rath et al.
CELLULAR SIGNALLING (2008)
Characterization of Ser338 Phosphorylation for Raf-1 Activation
Mengwei Zang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
p21 activated kinase 5 activates Raf-1 and targets it to mitochondria
Xiaochong Wu et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2008)
Electrostatic interactions positively regulate K-ras nanocluster formation and function
Sarah J. Plowman et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Galectin-1 is a novel structural component and a major regulator of H-Ras nanoclusters
Liron Belanis et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs
Kerry Inder et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes
Berta Casar et al.
MOLECULAR CELL (2008)
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation
Catherine Noble et al.
MOLECULAR CELL (2008)
High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes
Robert Brommage et al.
OBESITY (2008)
CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling
Thanashan Rajakulendran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
B- and C-RAF display essential differences in their binding to Ras - The isotype-specific N terminus of B-RAF facilitates ras binding
Andreas Fischer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Plasma membrane nanoswitches generate high-fidelity Ras signal transduction
Tianhai Tian et al.
NATURE CELL BIOLOGY (2007)
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
Bhaswati Pandit et al.
NATURE GENETICS (2007)
IQGAP1 modulates activation of B-Raf
Jian-Guo Ren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Integrating signals from RTKs to ERK/MAPK
M. M. McKay et al.
ONCOGENE (2007)
KSR and CNK:: two scaffolds regulating RAS-mediated RAF activation
A. Claperon et al.
ONCOGENE (2007)
Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1
Alireza S. Alavi et al.
CANCER RESEARCH (2007)
CK2 is a component of the KSR1 scaffold complex that contributes to Raf kinase activation
Daniel A. Ritt et al.
CURRENT BIOLOGY (2007)
Regulation of RKIP binding to the n-region of the Raf-1 kinase
Sungdae Park et al.
FEBS LETTERS (2006)
Functional analysis of the regulatory requirements of B-Raf and the B-RafV600E oncoprotein
T. Brummer et al.
ONCOGENE (2006)
Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-Ras diffusion and signaling
Sharon Eisenberg et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5
Alex von Kriegsheim et al.
NATURE CELL BIOLOGY (2006)
The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf
Kenta Terai et al.
EMBO JOURNAL (2006)
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
P Rodriguez-Viciana et al.
MOLECULAR CELL (2006)
The novel SAM domain protein aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway
JY Roignant et al.
GENES & DEVELOPMENT (2006)
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila
M Douziech et al.
GENES & DEVELOPMENT (2006)
Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein
DN Chadee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Regulation and role of Raf-1/B-Raf heterodimerization
LK Rushworth et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase
V Balan et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Erbin inhibits RAF activation by disrupting the Sur-8-Ras-Raf complex
PG Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Back to the roots: the remarkable RAF oncogene story
A. Zebisch et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
MJ Garnett et al.
MOLECULAR CELL (2005)
Raf-1 sets the threshold of Fas sensitivity by modulating Rok-α signaling
D Piazzolla et al.
JOURNAL OF CELL BIOLOGY (2005)
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
W Kolch
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton
SJ Plowman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
H-Ras dynamically interacts with recycling endosomes in CHO-K1 cells - Involvement of Rab5 and Rab11 in the trafficking of H-Ras to this pericentriolar endocytic compartment
GA Gomez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
IQGAP1 is a scaffold for mitogen-activated protein kinase signaling
M Roy et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation
N Trakul et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Ras plasma membrane signalling platforms
JF Hancock et al.
BIOCHEMICAL JOURNAL (2005)
CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation
A Ziogas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
RKIP downregulates B-Raf kinase activity in melanoma cancer cells
S Park et al.
ONCOGENE (2005)
Subcellular localization determines MAP kinase signal output
A Harding et al.
CURRENT BIOLOGY (2005)
B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms
NH Tran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Raf-1 regulates Rho signaling and cell migration
K Ehrenreiter et al.
JOURNAL OF CELL BIOLOGY (2005)
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase
K Terai et al.
EMBO REPORTS (2005)
Taming the hippo - Raf-1 controls apoptosis by suppressing MST2/Hippo
E O'Neill et al.
CELL CYCLE (2005)
Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism
G Laberge et al.
EMBO JOURNAL (2005)
Regulation of raf-1 by direct feedback phosphorylation
MK Dougherty et al.
MOLECULAR CELL (2005)
IQGAP1 binds ERK2 and modulates its activity
M Roy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus
I Perez de Castro et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
PTC Wan et al.
CELL (2004)
Rote of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
E O'Neill et al.
SCIENCE (2004)
The RAF proteins take centre stage
C Wellbrock et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis
S Ishibe et al.
MOLECULAR CELL (2004)
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis
O Yamaguchi et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Single-molecule imaging analysis of Ras activation in living cells
H Murakoshi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Membrane localization, oligomerization, and phosphorylation are required for optimal Raf activation
CA Goetz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling
PL Channavajhala et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Bimodal regulation of RAF by CNK in Drosophila
M Douziech et al.
EMBO JOURNAL (2003)
Protein phosphatase 2A positively regulates ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
S Ory et al.
CURRENT BIOLOGY (2003)
Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras
N Dumaz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1
TG Bivona et al.
NATURE (2003)
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
KC Corbit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition
NH Tran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Direct visualization of Ras proteins in spatially distinct cell surface microdomains
IA Prior et al.
JOURNAL OF CELL BIOLOGY (2003)
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis
S Ishibe et al.
MOLECULAR CELL (2003)
Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf
TM Lanigan et al.
FASEB JOURNAL (2003)
Structural determinants of Ras-Raf interaction analyzed in live cells
T Bondeva et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis
S Roy et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
14-3-3 antagonizes ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity
Y Light et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells
H Niv et al.
JOURNAL OF CELL BIOLOGY (2002)
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
A Nguyen et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells
XJ Jiang et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
AS Dhillon et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Dephosphorylation of Ser-259 regulates Raf-1 membrane association
M Kubicek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Critical contribution of linker proteins to Raf kinase activation
AN Anselmo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
KSR is a scaffold required for activation of the ERK/MAPK module
F Roy et al.
GENES & DEVELOPMENT (2002)
Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1
MW Zang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)
M Zhou et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Involvement of B-Raf in Ras-induced Raf-1 activation
S Mizutani et al.
FEBS LETTERS (2001)
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
J Müller et al.
MOLECULAR CELL (2001)
Positive and negative regulation of Raf kinase activity and function by phosphorylation
H Chong et al.
EMBO JOURNAL (2001)
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
M Jaumot et al.
ONCOGENE (2001)
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism
J Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
MEK kinase activity is not necessary for Raf-1 function
M Hüser et al.
EMBO JOURNAL (2001)
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
M Mikula et al.
EMBO JOURNAL (2001)
GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
IA Prior et al.
NATURE CELL BIOLOGY (2001)
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
A Chiloeches et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
BH Zhang et al.
EMBO JOURNAL (2000)
Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association
MT Yip-Schneider et al.
BIOCHEMICAL JOURNAL (2000)
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338
A Chaudhary et al.
CURRENT BIOLOGY (2000)
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the Raf kinase inhibitor protein
K Yeung et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Formation of the Ras dimer is essential for Raf-1 activation
K Inouye et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis
L Wojnowski et al.
MECHANISMS OF DEVELOPMENT (2000)
Share Paper
