Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 67, Issue 13, Pages 2215-2230Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0325-7
Keywords
Nuclear pore complexes; Nucleoporin; Transport; Mitosis; Kinetochores; Spindle; Checkpoint
Categories
Funding
- la Ligue Nationale contre le Cancer [2006-2009]
- Agence Nationale de la Recherche
- Canadian Institutes of Health Research
- Alberta Heritage Foundation for Medical Research
- Howard Hughes Medical Institute
- National Institutes of Health
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The trafficking of macromolecules between the cytoplasm and the nucleus is controlled by the nuclear pore complexes (NPCs) and various transport factors that facilitate the movement of cargos through the NPCs and their accumulation in the target compartment. While their functions in transport are well established, an ever-growing number of observations have also linked components of the nuclear transport machinery to processes that control chromosome segregation during mitosis, including spindle assembly, kinetochore function, and the spindle assembly checkpoint. In this review, we will discuss this evolving area of study and emerging hypotheses that propose key roles for components of the nuclear transport apparatus in mitotic progression.
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