Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 67, Issue 13, Pages 2145-2161Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0321-y
Keywords
Kinetochore; Spindle; Mitosis; Chromosome; Microtubule; Metaphase; Congression
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Funding
- Cancer Genomics Center
- Dutch Cancer Society
- Netherlands Organisation for Scientific Research (NWO)
- ERC
- EURYI
- Swiss National Science Foundation-Forderungs professorship
- Swiss Cancer League
- ETH Zurich
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Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.
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