Journal
MICROBES AND INFECTION
Volume 4, Issue 1, Pages 57-65Publisher
ELSEVIER
DOI: 10.1016/S1286-4579(01)01510-6
Keywords
HCV; CD8+T lymphocyte; tetramer; CD4+T lymphocyte; NKT cell
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Hepatitis C virus (HCV) readily causes a persistent infection, although some individuals spontaneously control infection. 'Successful' immune responses appear to be multi-specific and sustained-including a major role for CD4+ T cells. Some antiviral CD8+ T cells show reduced capacity to secrete antiviral cytokines either temporarily ('stunning') or in the long term ('stunting'). The co-ordination of multiple immune effector functions may be required to gain control of HCV. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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