Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 67, Issue 17, Pages 2957-2968Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0391-x
Keywords
Notch signaling; CBF1-independent Notch; Hes-1; Non-canonical Notch; Neural differentiation; Tumorigenesis
Categories
Ask authors/readers for more resources
Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available