Journal
TRENDS IN NEUROSCIENCES
Volume 25, Issue 1, Pages 10-11Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0166-2236(00)01982-2
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Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.
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