Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 16, Pages 2751-2767Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0590-5
Keywords
Dictyostelium discoideum; Dynamin; Presequence; Peroxisome; Fission; Cell adhesion
Categories
Funding
- NICHD
- Deutsche Forschungsgemeinschaft [MA 1081/7-2]
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Dictyostelium discoideum cells produce five dynamin family proteins. Here, we show that dynamin B is the only member of this group of proteins that is initially produced as a preprotein and requires processing by mitochondrial proteases for formation of the mature protein. Our results show that dynamin B-depletion affects many aspects of cell motility, cell-cell and cell-surface adhesion, resistance to osmotic shock, and fatty acid metabolism. The mature form of dynamin B mediates a wide range and unique combination of functions. Dynamin B affects events at the plasma membrane, peroxisomes, the contractile vacuole system, components of the actin-based cytoskeleton, and cell adhesion sites. The modulating effect of dynamin B on the activity of the contractile vacuole system is unique for the Dictyostelium system. Other functions displayed by dynamin B are commonly associated with either classical dynamins or dynamin-related proteins.
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