Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 3, Pages 397-404Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0581-6
Keywords
HLA-G; Mesenchymal stem cells; Immunoregulation
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HLA-G plays a particular role during pregnancy in which its expression at the feto-maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation.
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