Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 67, Issue 10, Pages 1607-1618Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0287-9
Keywords
Caspases; Serine proteases; Cathepsins; Apoptosis; Necrosis; Programmed cell death; Caspase-independent
Categories
Funding
- German Federal and State Governments
- Deutsche Forschungsgemeinschaft [BO-1933, GRK1104]
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Caspases are the most important effectors of apoptosis, the major form of programmed cell death (PCD) in multicellular organisms. This is best reflected by the appearance of serious development defects in mice deficient for caspase-8, -9, and -3. Meanwhile, caspase-independent PCD, mediated by other proteases or signaling components has been described in numerous publications. Although we do not doubt that such cell death exists, we propose that it has evolved later during evolution and is most likely not designed to execute, but to amplify and speed-up caspase-dependent cell death. This review shall provide evidence for such a concept.
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