Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 68, Issue 6, Pages 1091-1103Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0511-7
Keywords
Androgen receptor; FBI-1; Gene expression; POZ domain; Co-repressor
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Funding
- National Natural Science Foundation of China [30772001, 30671927]
- Beijing Municipal Natural Science Foundation [7102126]
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The pro-oncogene FBI-1, encoded by Zbtb7a, is a transcriptional repressor that belongs to the POK (POZ/BTB and Kruppel) protein family. In this study, we investigated a potential interaction between androgen receptor (AR) signaling and FBI-1 and demonstrated that overexpression of FBI-1 inhibited ligand-dependent AR activation. A protein-protein interaction was identified between FBI-1 and AR in a ligand-dependent manner. Furthermore, FBI-1, AR and SMRT formed a ternary complex and FBI-1 enhanced the recruitment of NCoR and SMRT to endogenous PSA upstream sequences. Our data also indicated that the FBI-1-mediated inhibition of AR transcriptional activity is partially dependent on HDAC. Interestingly, FBI-1 plays distinct roles in regulating LNCaP (androgen-dependent) and PC-3 cell (androgen-independent) proliferation.
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