Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 67, Issue 7, Pages 1025-1048Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0213-1
Keywords
CAS; BCAR1; NEDD9; Scaffold; Cancer; Invasion; Metastasis; Mitosis
Categories
Funding
- NIH [R01 CA63366, R01 CA113342, T32 CA009035, CA06927]
- NATIONAL CANCER INSTITUTE [T32CA009035, R01CA113342, P30CA006927, R01CA063366] Funding Source: NIH RePORTER
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Proteins of the CAS (Crk-associated substrate) family (BCAR1/p130Cas, NEDD9/HEF1/Cas-L, EFS/SIN and CASS4/HEPL) are integral players in normal and pathological cell biology. CAS proteins act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and have more recently been linked to a role in progenitor cell function. Reflecting these complex functions, over-expression of CAS proteins has now been strongly linked to poor prognosis and increased metastasis in cancer, as well as resistance to first-line chemotherapeutics in multiple tumor types including breast and lung cancers, glioblastoma, and melanoma. Further, CAS proteins have also been linked to additional pathological conditions including inflammatory disorders, Alzheimer's and Parkinson's disease, as well as developmental defects. This review will explore the roles of the CAS proteins in normal and pathological states in the context of the many mechanistic insights into CAS protein function that have emerged in the past decade.
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