Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 1, Issue 1, Pages 1-21Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b108586g
Keywords
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Funding
- NATIONAL CANCER INSTITUTE [P30CA043703, R01CA083917, P01CA048735] Funding Source: NIH RePORTER
- NCI NIH HHS [P30 CA43703, P01 CA48735, R01 CA83917] Funding Source: Medline
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Photodynamic therapy (PDT), a treatment for cancer and for certain benign conditions, utilizes a photosensitizer and light to produce reactive oxygen in cells. PDT is primarily employed to kill tumor and other abnormal cells, so it is important to ask how this occurs. Many of the photosensitizers currently in clinical or pre-clinical studies of PDT localize in or have a major influence on mitochondria, and PDT is a strong inducer of apoptosis in many situations. The purpose of this review is to critically evaluate all of the recently published research on PDT-induced apoptosis, with a focus on studies providing mechanistic insights. Components of the mechanism whereby PDT causes cells to undergo apoptosis are becoming understood, as are the influences of several signal transduction pathways on the response. Future research should be directed to elucidating the role(s) of the multiple steps in apoptosis in directing damaged cells to an apoptotic vs. necrotic pathway and for producing tumor ablation in conjunction with tissue-level mechanisms operating in vivo.
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