Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 17, Pages 2819-2833Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0048-9
Keywords
UbL; UBA; Proteasome; Degradation; Ubiquitin
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Funding
- NCI NIH HHS [CA052098, R01 CA052098-18, R01 CA052098] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA052098] Funding Source: NIH RePORTER
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The ubiquitin-proteasome pathway of protein degradation is one of the major mechanisms that are involved in the maintenance of the proper levels of cellular proteins. The regulation of proteasomal degradation thus ensures proper cell functions. The family of proteins containing ubiquitin-like (UbL) and ubiquitin-associated (UBA) domains has been implicated in proteasomal degradation. UbL-UBA domain containing proteins associate with substrates destined for degradation as well as with subunits of the proteasome, thus regulating the proper turnover of proteins.
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