Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 67, Issue 2, Pages 171-177Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0189-x
Keywords
Rho-kinase; ROCK; ROCK1; ROCK2; Fasudil; Y-27632
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The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked growing interest in the pharmacological potential of ROCK inhibitors beyond their current application in cardiovascular disease. This article discusses the therapeutic benefits of novel ROCK inhibitors in development, and highlights the recent advances in the current understanding of disease-dependent and isoform-specific functions of ROCK and their potential impact on future therapeutic strategies.
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