Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 19, Pages 3111-3126Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0064-9
Keywords
ATP-binding cassette; Membrane protein; Structure; Transporter; Lipid bilayer
Categories
Ask authors/readers for more resources
The ATP-binding cassette family is one of the largest groupings of membrane proteins, moving allocrites across lipid membranes, using energy from ATP. In bacteria, they reside in the inner membrane and are involved in both uptake and export. In eukaryotes, these transporters reside in the cell's internal membranes as well as in the plasma membrane and are unidirectional-out of the cytoplasm. The range of substances that these proteins can transport is huge, which makes them interesting for structure-function studies. Moreover, their abundance in nature has made them targets for structural proteomics consortia. There are eight independent structures for ATP-binding cassette transporters, making this one of the best characterised membrane protein families. Our understanding of the mechanism of transport across membranes and membrane protein structure in general has been enhanced by recent developments for this family.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available