Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 67, Issue 2, Pages 291-294Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0181-5
Keywords
Euchromatin; Heterochromatin; Histone methylation; gamma H2AX; Double strand break; gamma-Radiation
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Funding
- Australian Institute of Nuclear Science and Engineering
- National Health and Medical Research Council of Australia [566559]
- University of Melbourne
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The central dogma in radiation biology is that nuclear DNA is the critical target with respect to radiosensitivity. In accordance with the theoretical expectations, and in the absence of a conclusive model, the general consensus in the field has been to view chromatin as a homogeneous template for DNA damage and repair. This paradigm has been called into question by recent findings indicating a disparity in gamma-irradiation-induced gamma H2AX foci formation in euchromatin and heterochromatin. Here, we have extended those studies and provide evidence that gamma H2AX foci form preferentially in actively transcribing euchromatin following gamma-irradiation.
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