4.7 Review

Bitter peptides and bitter taste receptors

Journal

CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 10, Pages 1661-1671

Publisher

SPRINGER BASEL AG
DOI: 10.1007/s00018-009-8755-9

Keywords

Bitter peptide; casein hydrolysate; bitter receptor; T2Rs; structure

Funding

  1. NIDCD NIH HHS [R01DC007487] Funding Source: Medline
  2. NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC007487] Funding Source: NIH RePORTER

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Bitter peptides are a structurally diverse group of oligopeptides often generated in fermented, aged, and hydrolyzed food products that make them unfavorable for consumption. Humans perceive bitterness by a repertoire of 25 human bitter receptors, termed T2Rs. Knowledge of the structural features of bitter receptors and of the factors that stimulate bitter receptors will aid in understanding the mechanism responsible for bitter taste perception. This article reviews the current knowledge regarding structural features of bitter peptides and bitter taste receptors.

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