Journal
ARTHRITIS RESEARCH & THERAPY
Volume 4, Issue -, Pages S51-S61Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar573
Keywords
aggrecanase; collagenase; extracellular matrix; matrix metalloproteinases; proteinase inhibitor
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Funding
- NIH [AR40994]
- Wellcome Trust [057508]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR040994] Funding Source: NIH RePORTER
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Matrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated in numerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue inhibitors of metalloproteinases (TIMPs). This review highlights the structures and inhibition mechanism of TIMPs, the biological activities of TIMPs, the unique properties of TIMP-3, and the altered specificity towards MMPs achieved by mutagenesis. A potential therapeutic use of TIMP variants is discussed.
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