Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 23, Pages 3663-3673Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0099-y
Keywords
Mitochondria; HIF; ROS; Metastasis; Tumorigenesis; NADPH oxidase
Categories
Funding
- NIH [R01CA123067-03]
- LUNGevity Foundation
- Respiratory Health Association of Metropolitan Chicago
- NATIONAL CANCER INSTITUTE [R01CA123067] Funding Source: NIH RePORTER
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Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.
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