Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 14, Pages 2219-2230Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0013-7
Keywords
Periostin; Cancer; Tumorigenesis; Extracellular matrix (ECM); Epithelial-mesenchymal transition (EMT); Metastasis
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Funding
- National Nature Science Foundation of China [30570935, 30871242]
- NCETXMU
- Berkeley Scholar Fellowship
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Periostin, also called osteoblast-specific factor 2 (OSF-2), is a member of the fasciclin family and a disulfide-linked cell adhesion protein that has been shown to be expressed preferentially in the periosteum and periodontal ligaments, where it acts as a critical regulator of bone and tooth formation and maintenance. Furthermore, periostin plays an important role in cardiac development. Recent clinical evidence has also revealed that periostin is involved in the development of various tumors, such as breast, lung, colon, pancreatic, and ovarian cancers. Periostin interacts with multiple cell-surface receptors, most notably integrins, and signals mainly via the PI3-K/Akt and other pathways to promote cancer cell survival, epithelial-mesenchymal transition (EMT), invasion, and metastasis. In this review, aspects related to the function of periostin in tumorigenesis are summarized.
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