Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 23, Pages 3821-3826Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0129-9
Keywords
Bacterial membrane; Cationic peptide antibiotics; Drug target; Gramicidin S; Polymyxin; Respiratory enzymes
Categories
Funding
- Japan Society for the Promotion of Science [20570124, 18GS0314]
- Ministry of Education, Culture, Sports, Science and Technology, Japan. [18073004]
- Grants-in-Aid for Scientific Research [20570124] Funding Source: KAKEN
Ask authors/readers for more resources
Gramicidin S and polymyxins are small cationic cyclic peptides and act as potent antibiotics against Gram-negative and Gram-positive bacteria by perturbing integrity of the bacterial membranes. Screening of a natural antibiotics library with bacterial membrane vesicles identified gramicidin S as an inhibitor of cytochrome bd quinol oxidase and an alternative NADH dehydrogenase (NDH-2) and polymyxin B as an inhibitor of NDH-2 and malate: quinone oxidoreductase. Our studies showed that cationic cyclic peptide antibiotics have novel molecular targets in the membrane and interfere ligand binding on the hydrophobic surface of enzymes. Improvement of the toxicity and optimization of the structures and clinical uses are urgently needed for their effective application in combating drug-resistant bacteria.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available