Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 66, Issue 19, Pages 3103-3110Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0110-7
Keywords
Signal transduction; Protein phosphorylation; Enzyme evolution; Calcium; Calmodulin; Domain structure; Nuclear localisation
Categories
Ask authors/readers for more resources
PPEF/PP7 represents one of the five subfamilies of the PPP protein Ser/Thr phosphatases. Studies published in recent years point to a role of plant PP7 at a crossroad of different pathways of light and stress signalling. In animals, PPEFs are highly expressed in sensory neurons, and Drosophila PPEF phosphatase, rdgC, is essential for dephosphorylation of rhodopsin. Expression profiling suggests that mammalian PPEF may play a role in stress-protective responses, cell survival, growth, proliferation, and oncogenesis. Despite structural similarities of the catalytic domains and the fact that some of these phosphatases are involved in light perception both in animals and in plants, the plant and non-plant representatives of this group have distinct domain architecture and appear not to be orthologues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available