Journal
ARTHRITIS RESEARCH & THERAPY
Volume 4, Issue -, Pages S109-S116Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar576
Keywords
adhesion molecules; cytokines; inflammation; leukocytes; tumor necrosis factor
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Funding
- NIH [HL36003]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL036003, R37HL036003] Funding Source: NIH RePORTER
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Tumor necrosis factor (TNF) is the prototypic proinflammatory cytokine and endothelial cells are the principal cellular targets of its actions. Here I review the responses of endothelial cells to TNF, with emphasis on the induction of endothelial leukocyte adhesion molecules. I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules.
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