Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 22, Issue 1, Pages 111-120Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/107999002753452728
Keywords
-
Funding
- NHLBI NIH HHS [HL62215] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL062215] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Appropriate activation and differentiation of lymphocytes are critical for effective immune responses. These processes are normally guided by exposure of lymphocytes to different stimuli, which need to be appropriately integrated in order for lymphocytes to proceed along their activation and differentiation pathways. Although the early steps in lymphocyte activation have been studied extensively, the downstream effectors of these activation pathways and the basic mechanisms employed by lymphocytes to integrate the information provided by different activation stimuli are not fully characterized. Interferon (IFN) regulatory factor-4 (IRF-4) is a recently described member of the IRF family of transcription factors whose expression is largely restricted to lymphocytes. Genetic studies have indicated that IRF-4 is critical for the function of mature T and B cells. Here we review the role of IRF-4 as a downstream effector and potentially an integrator of lymphocyte responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available