Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 11, Pages 1706-1715Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-7584-6
Keywords
cancer progression; extracellular matrix; heparin; heparanase; angiogenesis; alternative splicing; metastasis; hypoxia
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Heparanase is an endoglycosidase that degrades heparan sulfate on the cell surface and extracellular matrix. The physiological functions of heparanase include heparan sulfate turnover, embryo development, hair growth, and wound healing. Heparanase is implicated in a variety of pathologies, such as tumor growth, angiogenesis, metastasis, inflammation, and glomerular diseases. Heparanase overexpression in a variety of malignant tumors suggests that it could be a target for anti-cancer therapy.
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