Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 5, Pages 700-712Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7486-z
Keywords
thrombospondin; angiogenesis; cancer; transforming growth factor beta; tumor dormancy
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL049081] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL049081, R01 HL049081-14] Funding Source: Medline
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The thrombospondins (TSPs) are a family of five proteins that are involved in the tissue remodeling that is associated with embryonic development, wound healing, synaptogenesis, and neoplasia. These proteins mediate the interaction of normal and neoplastic cells with the extracellular matrix and surrounding tissue. In the tumor microenvironment, TSP-1 has been shown to suppress tumor growth by inhibiting angiogenesis and by activating transforming growth factor beta. TSP-1 inhibits angiogenesis through direct effects on endothelial cell migration and survival, and through effects on vascular endothelial cell growth factor bioavailability. In addition, TSP-1 may affect tumor cell function through interaction with cell surface receptors and regulation of extracellular proteases. Whereas the role of TSP-1 in the tumor microenvironment is the best characterized, the other TSPs may have similar functions.
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