Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 65, Issue 15, Pages 2372-2384Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8053-y
Keywords
Alzheimer's disease; Alzheimer's pathology; dentate neurogenesis; neural progenitor; neural stem cell; stem cell renewal; stem cell differentiation; stem cell graft
Categories
Funding
- NIA NIH HHS [R01 AG020924, AG20924] Funding Source: Medline
- NINDS NIH HHS [NS 043507, R01 NS054780, NS054780, R01 NS043507] Funding Source: Medline
Ask authors/readers for more resources
Alzheimer's disease (AD) is characterized by the deposition of beta-amyloid peptides (A beta) and a progressive loss of neurons leading to dementia. Because hippocampal neurogenesis is linked to functions such as learning, memory and mood, there has been great interest in examining the effects of AD on hippocampal neurogenesis. This article reviews the pertinent studies and tries to unite them in one possible disease model. Early in the disease, oligomeric A beta may transiently promote the generation of immature neurons from neural stem cells (NSCs). However, reduced concentrations of multiple neurotrophic factors and higher levels of fibroblast growth factor-2 seem to induce a developmental arrest of newly generated neurons. Furthermore, fibrillary A beta and down-regulation of oligodendrocyte-lineage transcription factor-2 (OLIG2) may cause the death of these nonfunctional neurons. Therefore, altering the brain microenvironment for fostering apt maturation of graft-derived neurons may be critical for improving the efficacy of NSC transplantation therapy for AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available