Journal
MICROBES AND INFECTION
Volume 4, Issue 1, Pages 67-73Publisher
ELSEVIER
DOI: 10.1016/S1286-4579(01)01511-8
Keywords
HIV nuclear import; preintegration complex
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Funding
- NIAID NIH HHS [K08 AI01866, R01 AI45324] Funding Source: Medline
- NIMH NIH HHS [P30 MH59037] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI045324, K08AI001866] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [P30MH059037] Funding Source: NIH RePORTER
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HIV infection of non-dividing cellular targets like macrophages requires successful passage of the viral preintegration complex (PIC) across an intact nuclear envelope. Unique but redundant nuclear import signals reside within the HIV integrase, matrix, and Vpr proteins as well as the 'DNA flap'; these signals appear to facilitate PIC transport through the limiting nuclear pores. We discuss recent studies that have advanced our understanding of this key step in the HIV life cycle. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All lights reserved.
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